It is written in fluent technobabble. If you can finish it, since it is so confusingly written, ask yourself the question, "Why not just eat fewer Calories than you burn?"
"When obesity overloads the body with excess nutrients, parts start to fail. Obesity contributes to heart disease, stroke, diabetes, high blood pressure, some cancers, liver disease, immune dysfunction, painful joints, and a host of other problems. With so many parts of the body affected, studies of the health effects of obesity that concentrate on one body organ or system may overlook common underlying events occurring at the cellular level throughout the body...It is thinking like this that will bankrupt us on the way to killing ourselves by flabicide.
The authors point to work by Dr. Gökhan S. Hotamisligil of the Harvard University School of Public Health and others who have proposed that metabolic problems arise when the body's cells have to deal with an excess of nutrients. An excess occurs when the body consumes more energy in food than it needs to meet ongoing energy requirements. Hotamisligil and other scientists have found that the oversupply triggers several similar, harmful responses in a variety of cell types: liver cells, the cells lining blood vessels, muscle cells, immune cells and even brain cells.
According to the Science Perspective article, identifying similarities in how different kinds of cells respond to excess nutrients might reveal why so many people put on too much weight and then are unable to lose it...
The authors conclude that more integrative approaches, those that seek out underlying disease mechanisms occurring in cells and tissues throughout the body, rather than those that study single body parts or systems, might more readily lead to strategies for preventing or treating obesity and the many medical problems that accompany it."
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