"Building on mounting evidence that implicates infection-fighting cells found in obese fat tissue in the growing problem of insulin resistance and Type 2 diabetes, researchers at the University of California, San Diego, School of Medicine have identified a particular subset of cells that are linked to obesity-associated insulin resistance, and that offer a promising new target for the treatment of diabetes. They showed that depletion of these cells, called CD11c-positive, in obese mice resulted in a reversal of obesity-associated insulin resistance...There is only one target - the number of Calories in relative to the number of Calories out.
'The CD11c+ macrophages appear to cause insulin resistance and diabetes," said Neels. "If the results of our work with mice translate into humans, suppressing this macrophage subset could offer a very promising target for Type II diabetes treatments.'"
Any other target is a mirage.
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