An expert consensus panel from the European Atherosclerosis Society (EAS) has issued new recommendations for the management of patients with elevated triglycerides and low HDL-cholesterol levels [1]. For patients with high triglycerides or low HDL-cholesterol levels, the first task is lifestyle modification, but barring that, fibrates, niacin, or even the intensification of statin therapy is recommended.What a surprise.
Interestingly, the recommendations are published on the heels of the discontinuation of the Atherothrombosis Intervention in Metabolic Syndrome with Low HDL Cholesterol/High Triglyceride and Impact on Global Health Outcomes (AIM-HIGH) study. As reported by heartwire , the National Heart, Lung, and Blood Institute–sponsored study of high-dose extended-release niacin (Niaspan, Abbott), given in addition to statin therapy in patients with a history of cardiovascular disease, high triglycerides, and low levels of HDL cholesterol was halted 18 months ahead of schedule because niacin offered no additional benefits in this patient population.
Not.
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