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Sunday, September 11, 2011

Researchers Find Missing Genes May Separate Couch Potato From Active Cousin

This time for sure. This is the reason some people are fit and others are fat slobs.
You may think your lack of resolve to get off the couch to exercise is because you're lazy, but McMaster University researchers have discovered it may be you are missing key genes.

The researchers made their unexpected finding while working with healthy, specially-bred mice, some of which had two genes in muscle essential for exercise removed. The genes control the protein AMP-activated protein kinase (AMPK), an enzyme that is switched on when you exercise.

"Mice love to run," said Gregory Steinberg, associate professor of medicine in the Michael G. DeGroote School of Medicine and Canada Research Chair in Metabolism and Obesity.

"While the normal mice could run for miles, those without the genes in their muscle could only run the same distance as down the hall and back. It was remarkable. The mice looked identical to their brothers or sisters but within seconds we knew which ones had the genes and which one didn't."

The researchers found the mice without the muscle AMPK genes had lower levels of mitochondria and an impaired ability for their muscles to take up glucose while they exercise.

"When you exercise you get more mitochondria growing in your muscle. If you don't exercise, the number of mitochondria goes down. By removing these genes we identified the key regulator of the mitochondria is the enzyme AMPK," said Steinberg.
Logically extending this important research, it is clear that underachieving students are genetically stupid and teaching them is a waste of time.

Say adios to affirmative action as we know it.

Say hello to an army of people incapable of even the most menial of tasks requiring some skills.


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