Obesity Genes Revealed

Still think they will find a genetic "cure" to your overweight/obesity?

Not. Unless you are a fruit fly. Even then, it's probably uncertain.

"A study of 228 women has revealed genetic variants responsible for body shape. Based on work in the fruit fly Drosophila melanogaster, research published today in the open access journal BMC Genetics identifies natural variation in the human LAMA5 gene as a key determinant of weight...

On the basis of the results of these fly experiments, the research team then tested three common variations in the human LAMA5 gene and discovered two gene variants that were associated with body shape, one in women of European American descent and the other affecting women of American African descent. As De Luca reports, 'We found one variant to be associated with weight and lean mass in both ethnic groups. This variant was also associated with height, total fat mass and HDL-cholesterol, but only in European American women. A different variant was associated with triglyceride levels and HDL-cholesterol in African American women.'"

It also apparently depends on whether you are an African American or European American relative of a fruit fly.

"The use of flies in a study of human obesity may seem strange, but according to De Luca 'Insects store fat like mammals do, as lipid droplets accumulated in the fat body, the functional equivalent of both mammalian liver and white adipose tissue'. (sic) She adds that, 'Drosophila share many components of fat biosynthesis, degradation and regulation with humans, including many of those implicated in diabetes and obesity'". (sic)

The fruit fly also shares a brain component with this researcher.