"Obesity very often leads to insulin resistance, and now researchers reporting in the July 8 issue of Cell Metabolism, a Cell Press publication, have uncovered another factor behind that ill consequence. The newly discovered culprit - a protein known as pigment epithelium-derived factor (PEDF for short) - is secreted by fat cells. They also report evidence to suggest that specifically blocking that protein's action may reverse some of the health complications that come with obesity."There is no "new culprit."
It is the same culprit - being too fat.
Period.
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