"New research from Columbia University Medical Center has illuminated a previously unknown leptin-serotonin pathway in the brain that simultaneously promotes appetite and bone mass accrual. The research, which explains how leptin - well-known appetite-suppressing hormone - acts in the brain, is published in the Sept. 4 issue of Cell.First, note that after all the hullabaloo over leptin, these researchers claim that prior studies got it all wrong about where and how it works.
When the leptin-serotonin pathway is turned on in mice, the researchers found, appetite increases, the animals eat more, gain weight, and their bone mass increases. When the pathway is turned off, mice eat less, lose weight, and their bones weaken. Furthermore, leptin was found to not act in the hypothalamus as previously thought, but in the brain stem acting on serotonin, a hormone that in the brain acts to control appetite, mood and anger."
Second:
It is a waste.
Fatosity is caused by only one thing - more Calories in than out.
You can bet that as more resources are wasted pursuing a "cure" to overfatness, they will discover additional mistakes of the past and that these discoveries will become the past mistakes of the future.
The problem is known with 100% certainty - too many Calories in.
The cure is known with 100% certainty - more Calories out than in.
End of discussion and end the madness.
"Dr. Karsenty points out that these current findings may have more influence on developing a new way to reduce appetite and obesity than preventing osteoporosis.Don't bother.
'It will be difficult to turn on the pathway to strengthen bone without increasing appetite at the same time,' Dr. Karsenty said. 'But this finding shows that it is feasible to alter parts of the leptin-serotonin pathway to decrease appetite without weakening bone.'"
It is a waste.
Fatosity is caused by only one thing - more Calories in than out.
You can bet that as more resources are wasted pursuing a "cure" to overfatness, they will discover additional mistakes of the past and that these discoveries will become the past mistakes of the future.
The problem is known with 100% certainty - too many Calories in.
The cure is known with 100% certainty - more Calories out than in.
End of discussion and end the madness.
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4 comments:
First: The author of this study does not understand a bit about the physiology. If everything is just calories in and calories out then every one dieting will reduce weight and become lean. There are lot of genetic predisposition, environmental factors that contribute to the obesity. After I read this column I went and saw the paper. This paper is very elegant utilizes the cutting edge conditional mutagenesis in a mice and demonstrates an important physiological pathway rather than like the author of this column just write anything. I am sure it took them 4-5 years to finish this study not 20 minutes to write this column.
Hello, marie therese and welcome to Fitness Watch.
You are clearly mistaken.
There is nothing that trumps the Laws of Thermodynamics.
Everything is just Calories in and Calories out when it comes to weight loss and weight gain.
There is no species anywhere that will not gain weight if it consumes more Calories than it burns.
There is no species anywhere that will not lose weight if it burns more Calories than it consumes.
There is no genetic make-up, environment or anything else that can change this.
If you can demonstrate one thing that can, please let Fitness Watch know.
Thanks for visiting.
May be you can answer me. What makes the body regulate the calories in and calories out. It is hormones and leptin, ghrelin, serotonin are among them. Correct me if I am wrong. In other words calories in and calories out or the capability of the body to determine that is controlled by hormones and many more physiological pathways.
Thanks for your reply.
You have yet to demonstrate one living thing that will not lose weight if it consumes fewer Calories than it burns or that will not gain weight if it consumes more Calories than it burns.
As to your most recent post...
Consider yourself corrected, as you are wrong.
It is Calories in and Calories out.
Leptin, ghrelin and serotonin are, for all practical purposes, acaloric and contribute nothing to weight.
I know where you are coming from and it is a meaningless place as it will never result in a solution to overweight or obesity in the real world for the foreseeable future.
At best, it is an academic exercise - an ivory tower Nero fiddling as sick care systems (instead of Calories) burn.
The only thing that matters for the here and now is the difference between Calories in and Calories out.
Everything else is unfounded, impractical speculation.
Period.
End.
As my time is not unlimited, please understand if I do not respond to any more of your postings which might be in a vein similar to your other two.
I will await your identification of the critter(s) that defy/ies the Laws of Thermodynamics.
Regards.
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