"The National Institutes of Health announced today that it will fund 22 grants on genome-wide studies of how epigenetic changes — chemical modifications to genes that result from diet, aging, stress, or environmental exposures — define and contribute to specific human diseases and biological processes."So it is not just the genes, it is how they are modified that affects their expression.
What this means, is that the variables are growing - big and fast.
This means that finding the genetic "cure" is even tougher.
They were wrong about the number of genes in the genome. There are far fewer than originally thought.
And, between 24% and 30% appear to be involved in overfatness - so they estimate.
However, the difference in genes between humans and mice is only 1%:
They were wrong about the number of genes in the genome. There are far fewer than originally thought.
And, between 24% and 30% appear to be involved in overfatness - so they estimate.
However, the difference in genes between humans and mice is only 1%:
"Scientists think that the mouse genome will be even important than the human genome to medicine and human welfare. That seems bizarre: why is that? The reason is that, because of the relatively 'recent' divergence of the mouse and human lineages from our common ancestor (about 75 million years ago), an astonishing 99% of mouse genes turn out to have analogues in humans. Not only that, but great tracts of code are syntenic - that means the genes appear in the same order in the two genomes...
The astonishingly close homology that has been revealed in the code between mouse and human genome extends to functionality. Many homologous genes have identical functions in the two species, anatomy, physiology and metabolism are similar and genetic disease pathology can be very similar. So the fact that we can study the mouse empirically, means that we can identify the functions of genes in people and both understand human disease pathology and create ways to treat it." (source)That is why, if you are going to attempt a genetic "cure" for fatosity, it is better to work on turning fat people into mice, where there is apparent success in controlling weight.
For more info, go to www.turnfatpeopleintomice.com
Here are mouse success stories: (Note size comparison with 747 in the first image)
Fat mouse (lower) vs. skinny mouse:
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