A detailed study of heart muscle function in mice has uncovered evidence to explain why exercise is beneficial for heart function in type 2 diabetes. The research team, led by scientists at the Johns Hopkins University School of Medicine, found that greater amounts of fatty acids used by the heart during stressful conditions like exercise can counteract the detrimental effects of excess glucose and improve the diabetic heart's pumping ability in several ways. The findings also shed light on the complex chain of events that lead to diabetic cardiomyopathy, a form of heart failure that is a life-threatening complication of type 2 diabetes.Really.
The study, described in an article published online on July 17, 2012 in the journal Diabetes, was conducted in a mouse model of type 2 diabetes, and focused on the exchange of energy within heart muscle cells. The researchers looked at the impact of glucose and fatty acids, which are different types of "fuel" that provide energy to the cells - and how those affect heart muscle function.
"Our work offers a new view of the role of fatty acids in diabetic hearts under stress, and suggests potential new therapies to improve heart function," says Miguel Aon, Ph.D., assistant professor of medicine at the Johns Hopkins University School of Medicine and a senior author of the study article. "It has been commonly assumed that fatty acids were detrimental to heart muscle function, but our study showed the opposite to be true in the diabetic heart."
Who cares to know why?
The fat are not going to engage in physical activity anyway. (Training, that is. Exercise is useless or worse.)
Anything else is letting them off the hook at our expense.
If they want to live, and believe the conventional wisdom, then they will move.
If not, and the conventional wisdom is correct, good riddance.
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