Joint research between the University of Michigan and the Argentina-based National Council of Science and Technology (CONICET) has shed light on one of the most frustrating mysteries of weight loss -- why the weight inevitably comes back.Timing means nothing.
A novel animal model showed that the longer mice remained overweight, the more "irreversible" obesity became, according to the new study that appeared online ahead of print Oct.24 in the Journal of Clinical Investigation.
Over time, the static, obese state of the mice reset the "normal," body weight set point to become permanently elevated, despite dieting that initially worked to shed pounds, authors say.
"Our model demonstrates that obesity is in part a self-perpetuating disorder and the results further emphasize the importance of early intervention in childhood to try to prevent the condition whose effects can last a lifetime," says senior author Malcolm J. Low, M.D., Ph.D., professor of molecular and integrative physiology and internal medicine.
"Our new animal model will be useful in pinpointing the reasons why most adults find it exceedingly difficult to maintain meaningful weight loss from dieting and exercise alone."
Anytime you consume fewer Calories than you burn, you will lose weight.
Anytime you consume more Calories than you burn, you will gain weight.
Anytime you make excuses for your lack of willpower and resulting failure, you will remain fat.