'Fasting Switch' Disabled By Chronically Elevated Blood Sugar Levels

A sack from Salk.

"Continually revved up insulin production, the kind that results from overeating and obesity, slowly dulls the body's response to insulin. As a result, blood sugar levels start to creep up, setting the stage for diabetes-associated complications such as blindness, stroke and renal failure. To make matters even worse, chronically elevated blood sugar concentrations exacerbate insulin resistance.

The vicious circle gets rolling, researchers at the Salk Institute for Biological Studies discovered, when out-of-control blood sugar levels disable the molecular switch that normally shuts off sugar production in the liver in response to rising levels of insulin."

Note that the precondition is being overweight or obese.

"Three years ago, Montminy discovered a "fasting switch" called CRTC2 (formerly known as TORC2) that flips on glucose production in the liver when blood glucose levels run low during the night. After a meal, the hormone insulin normally shuts down CRTC2 ensuring that blood sugar levels don't rise too high.

In many patients with type II diabetes, however, CRTC2 no longer responds to rising insulin levels and as a result the liver acts like a sugar factory on overtime, churning out glucose throughout the day, even when blood sugar levels are high."

See, even assuming any of this tripe is true, the matter is from being too fat first.

Become not-too-fat, i.e., lose weight, and Voila!, problem solved.

Otherwise you have a future of:

"'drugs that decrease gluconeogenesis...'"

Drugs.